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Of the three BCAA’s, Leucine plays a special role in skeletal muscle metabolism by exerting anti-catabolic and anabolic effects on protein metabolism. Leucine incorporation into skeletal muscle has long been used as a marker of muscle protein synthesis and oxidation. Because leucine so powerfully stimulates muscle protein synthesis, some experts have suggested that leucine supplementation could be used to combat age-associated skeletal muscle mass loss.
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